Ammonia → HCID 11292513, compound

HRID 2373918Notes

Reaction equation

CC(O)C.[CH2:5]([O:12][C:13]1[CH:14]=[C:15]([C:21]2[N:22]=[C:23]([CH:31]3[CH2:34][CH2:33][CH2:32]3)[N:24]3[CH:29]=[CH:28][N:27]=[C:26](Cl)[C:25]=23)[CH:16]=[CH:17][C:18]=1[O:19][CH3:20])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[NH3:35]>C(Cl)Cl>[CH2:5]([O:12][C:13]1[CH:14]=[C:15]([C:21]2[N:22]=[C:23]([CH:31]3[CH2:34][CH2:33][CH2:32]3)[N:24]3[CH:29]=[CH:28][N:27]=[C:26]([NH2:35])[C:25]=23)[CH:16]=[CH:17][C:18]=1[O:19][CH3:20])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

Conditions

Temperature: 110 °C

Procedure

An iPrOH (5 ml)/DCM (4 ml) solution of 1-(3-benzyloxy-4-methoxyphenyl)-8-chloro-3-cyclobutylimidazo[1,5-a]pyrazine (290 mg, 87%, 0.601 mmol), cooled to −78° C. in a dry ice/acetone bath, was charged with liquid NH3 for 15 min. The sealed tube was equipped with a Teflon washer, sealed and heated 110° C. for 14 h. After that time, the excess NH3 and the solvent were evaporated. The remaining material was purified by chromatography on silica gel to obtain the title compound as a brown oil. The impurities that could not be removed by conventional methods (eg. TLC, HPLC etc.), were removed by SCX column (washed with 7 ml of DCM, 7 ml of MeOH and 7 ml of 2 N NH3 in MeOH); 1H NMR (CDCl3, 400 MHz) δ 2.00-2.24 (m, 2H), 2.42-2.66 (m, 4H), 3.78 (quintet, 1H, J=8.4 Hz), 3.95 (s, 3H), 4.95 (brs, 2H), 5.23 (s, 2H), 6.98-7.02 (m, 2H), 7.07 (d, 1H, J=5.2 Hz), 7.17 (d, 1H, J=2.0 Hz), 7.23 (dd, 1H, J=2.0 and 8.0 Hz), 7.29-7.45 (m, 5H); MS (ES): 401.1 (M+1).

Workup

customsealed
customAfter that time, the excess NH3 and the solvent were evaporated
customThe remaining material was purified by chromatography on silica gel

Sources & evidence

ORD record: ord-09f6803280c7498bbde4a4465e23d9b5
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07459554B2

Reaction notes

Loading…