Water → HCID 59519199, compound

HRID 237393Notes

Reaction equation

HRID 237393 reaction equation
C([O:3][C:4]([C:6]1[S:33][C:9]2[N:10]=[C:11]([NH2:32])[N:12]=[C:13]([C:14]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[N:16](S(C4C=CC=CC=4)(=O)=O)[CH:15]=3)[C:8]=2[CH:7]=1)=[O:5])C.[OH-].[K+].O>C(O)C>[NH2:32][C:11]1[N:12]=[C:13]([C:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[NH:16][CH:15]=2)[C:8]2[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[S:33][C:9]=2[N:10]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 59519309HCID 59519309, compound

Product 1

HCID 59519199HCID 59519199, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-amino-4-(1-benzenesulfonyl-1H-indol-3-yl)-thieno[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (80 mg, 0.17 mmol) in ethanol (6 ml) was heated to 65° C., 2M potassium hydroxide added (0.25 ml, 3 equiv.) and stirred overnight. Water was added and the volatile removed in vacuo. The solution was then neutralised and freeze dried.

Workup

  1. customthe volatile removed in vacuo
  2. customfreeze dried

Sources & evidence

ORD record
ord-8eed4f7656b44eddb3ffc3e0a07a3bc3
Source dataset
uspto-grants-2014_02
Patent number
US08642594B2

Reaction notes

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