Hydrochloric Acid → HCID 131727209, compound

HRID 2373969Notes

Reaction equation

HRID 2373969 reaction equation
[ClH:1].O1CCOCC1.[CH2:8]([NH:15][C:16]1[CH:21]=[C:20]([O:22][C:23]2[CH:28]=[CH:27][C:26]([NH:29]C(=O)OC(C)(C)C)=[CH:25][C:24]=2[F:37])[CH:19]=[CH:18][N:17]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[ClH:1].[NH2:29][C:26]1[CH:27]=[CH:28][C:23]([O:22][C:20]2[CH:19]=[CH:18][N:17]=[C:16]([NH:15][CH2:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH:21]=2)=[C:24]([F:37])[CH:25]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59852895HCID 59852895, compound

Product 1

HCID 131727209HCID 131727209, compoundYield 100%

Procedure

Anhydrous HCl in dioxane (4N, 2.00 mL, 8.00 mmol, 165 eq) was added to tert-butyl 4-(2-(benzylamino)pyridin-4-yloxy)-3-fluorophenylcarbamate (0.020 g, 0.0489 mmol, 1.0 eq) and the reaction mixture was stirred at room temperature for 12 h. The reaction mixture was concentrated in vacuo to afford the title compound (0.017 g, 100%) a solid that was used without further purification. MS(ESI+) m/z 310 (M+H)+; HRMS(ESI+) calcd.: 310.1356, found: 310.1364.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-9c4b4ad2c55a4668ac009f75099ef42d
Source dataset
uspto-grants-2008_12
Patent number
US07459562B2

Reaction notes

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