Dimethylformamide → Ethyl 3-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)-3-oxopropanoate

HRID 2374059Notes

Reaction equation

HRID 2374059 reaction equation
C([C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:16]=[CH:15][C:14]([NH:17][C:18](=[O:25])[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:13][C:12]=2[F:26])[CH:7]=[CH:6][N:5]=1)(=O)N.C[N:28](C=O)C>>[NH2:28][C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:16]=[CH:15][C:14]([NH:17][C:18](=[O:25])[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:13][C:12]=2[F:26])[CH:7]=[CH:6][N:5]=1

Participants

3

Reactant 2

HCID 6228DimethylformamideHCID 59853090Ethyl 3-(4-(2-carbamoylpyridin-4-yloxy)-3-fluorophenylamino)-3-oxopropanoate

Product 1

HCID 59853026Ethyl 3-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)-3-oxopropanoateYield 86%

Procedure

Prepared in a manner similar to that which is described in Step A of Example 91. Ethyl 3-(4-(2-carbamoylpyridin-4-yloxy)-3-fluorophenylamino)-3-oxopropanoate (900 mg, 2.5 mmol) in DMF (10.0 mL) was converted to ethyl 3-(4-(2-aminopyridin-4-yloxy)-3-fluorophenylamino)-3-oxopropanoate (710 mg, 86% yield). MS(ESI+) m/z 334.26 (M+H)+.

Workup

  1. customPrepared in a manner similar to that which

Sources & evidence

ORD record
ord-64813944858c4eed96c32799bf6e2155
Source dataset
uspto-grants-2008_12
Patent number
US07459562B2

Reaction notes

Loading…