sodium (1Z)-1-cyanoprop-1-en-2-olate → HCID 178467935, compound

HRID 237407Notes

Reaction equation

HRID 237407 reaction equation
[Br:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH:11]=O)[CH:9]=2)[NH:4][N:3]=1.[C:13](/[CH:15]=[C:16](\[O-:18])/[CH3:17])#[N:14].[Na+]>>[Br:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8](/[CH:11]=[C:15](/[C:16](=[O:18])[CH3:17])\[C:13]#[N:14])[CH:9]=2)[NH:4][N:3]=1

Participants

3

Reactant 2

HCID 23687916sodium (1Z)-1-cyanoprop-1-en-2-olateHCID 178519375HCID 178519375, compound

Product 1

HCID 178467935HCID 178467935, compound

Procedure

The title compound was prepared from 2.85 g (70% purity, 8.87 mmol) 3-bromo-1H-indazole-5-carbaldehyde (Example 10A) and 1.03 g (9.75 mmol) sodium (1Z)-1-cyanoprop-1-en-2-olate in analogy to the procedure described in Example 9A yielding 1.12 g (43% of th.) of product which was used in subsequent steps without further purification.

Workup

  1. customyielding 1.12 g (43% of th.) of product which
  2. customwas used in subsequent steps without further purification

Sources & evidence

ORD record
ord-91a338ab524f4313ac064a6b678c3af1
Source dataset
uspto-grants-2014_02
Patent number
US08642595B2

Reaction notes

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