反应详情

温度

80 °C

1-[1,8]Naphthyridin-4-yl-ethanol (1.44 g, 8.26 mmol) was dissolved in EtOAc (250 mL), treated with IBX (7.8 g, 24.8 mmol) and heated to 80° C. for 6 h. The solution was cooled to RT and the solids removed by filtration. The product was purified (SGC using MeCN eluant) yielding the title compound (1.22 g). MS (ESI+) for m/z 173 (M+H)+. 1H NMR (CDCl3) δ 9.13 (d, 1H), 9.03 (dd, 1H), 8.85 (dd, 1H), 7.70 (d, 1H), 7.46 (dd, 1H), 2.64 (s, 3H).

1. additiontreated with IBX (7.8 g, 24.8 mmol)
2. temperatureThe solution was cooled to RT
3. customthe solids removed by filtration
4. customThe product was purified (SGC using MeCN eluant)