Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1H-1,2,4-Triazole | HCID 9257 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Fluoro-5-nitrobenzonitrile | HCID 519417 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 63812334 | HCID 63812334 | — |
Reaction Steps
2-Fluoro-5-nitro-benzonitrile (1.0 g, 6.0 mmol) was dissolved in anhydrous DMF (6 mL), then treated with [1,2,4]-triazole (0.46 g, 6.7 mmol), cesium carbonate (2.9 g, 8.9 mmol), and heated (50° C.) overnight. After cooling to RT, the mixture was treated with water and the solid title compound collected by filtration (1.14 g). MS (ESI+) for m/z 216 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07462600B2 |
|---|
| Source dataset | uspto-grants-2008_12 |
|---|
| ORD ID | ord-c462e9405f1b4f0ab408b1267dd0a4bd |
|---|
| Source note | uspto-grants-2008_12 |
|---|
