Water → HCID 63812334, compound

HRID 2374146Notes

Reaction equation

HRID 2374146 reaction equation
F[C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[C:4]#[N:5].[NH:13]1[CH:17]=[N:16][CH:15]=[N:14]1.C(=O)([O-])[O-].[Cs+].[Cs+].O>CN(C=O)C>[N+:10]([C:7]1[CH:8]=[CH:9][C:2]([N:13]2[CH:17]=[N:16][CH:15]=[N:14]2)=[C:3]([CH:6]=1)[C:4]#[N:5])([O-:12])=[O:11]

Participants

6

Reactant 4

HCID 962WaterHCID 92571H-1,2,4-TriazoleHCID 10796Cesium carbonateHCID 5194172-Fluoro-5-nitrobenzonitrile

Product 1

HCID 63812334HCID 63812334, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
50 °C

Procedure

2-Fluoro-5-nitro-benzonitrile (1.0 g, 6.0 mmol) was dissolved in anhydrous DMF (6 mL), then treated with [1,2,4]-triazole (0.46 g, 6.7 mmol), cesium carbonate (2.9 g, 8.9 mmol), and heated (50° C.) overnight. After cooling to RT, the mixture was treated with water and the solid title compound collected by filtration (1.14 g). MS (ESI+) for m/z 216 (M+H)+.

Workup

  1. temperatureAfter cooling to RT
  2. filtrationthe solid title compound collected by filtration (1.14 g)

Sources & evidence

ORD record
ord-c462e9405f1b4f0ab408b1267dd0a4bd
Source dataset
uspto-grants-2008_12
Patent number
US07462600B2

Reaction notes

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