Glyoxal → 5-Quinoxalinol

Participants

Reaction Conditions

Reaction Steps

2,3-Diaminophenol (2 g) in 10 ml acetic acid and 20 ml 4M sodium acetate and a solution of oxalaldehyde (4.8 g) dissolved in 20 ml water were combined and the resulting mixture was heated at 60° C. for 1.5 h. After cooling to RT water (100 ml) was added and the mixture extracted with EtOAc. The organic layer was dried over Na2SO4, and concentrated to give quinoxalin-5-ol. MS (ESI+) for m/z 147 [M+H]+.

Provenance & Evidence