Indole → HCID 67426066, compound

HRID 237418Notes

Reaction equation

HRID 237418 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.Cl[C:11]1[N:16]=[CH:15][N:14]=[C:13](Cl)[CH:12]=1>>[N:14]1[CH:13]=[CH:12][CH:11]=[N:16][CH:15]=1.[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 798IndoleHCID 709434,6-Dichloropyrimidine

Product 1

HCID 67426066HCID 67426066, compound

Procedure

In step 2, indole c is reacted with dichloropyrimidine d to yield indole pyrimidine compound e. The reaction of step 2 may be effected in the presence of HOBt and potassium carbonate under polar solvent conditions.

Sources & evidence

ORD record
ord-a164255e00224692b598273c6fc9867f
Source dataset
uspto-grants-2014_02
Patent number
US08642601B2

Reaction notes

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