Hydrochloric Acid → 1-(2-Fluoro-4-(trifluoromethyl)phenyl)piperazine

HRID 2374232Notes

Reaction equation

HRID 2374232 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:15]=2[F:24])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[F:24][C:15]1[CH:16]=[C:17]([C:20]([F:21])([F:22])[F:23])[CH:18]=[CH:19][C:14]=1[N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 534855174-(2-Fluoro-4-trifluoromethylphenyl)piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 468374951-(2-Fluoro-4-(trifluoromethyl)phenyl)piperazineYield 95%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A mixture of 3.11 g (9 mmol) 4-(2-Fluoro-4-trifluoromethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester in 20 ml dioxane was treated with 8.93 ml 4N HCl in dioxane for 2 h at 80° C. The mixture was concentrated and treated with 20 ml water, 20 ml 2M Na2CO3 and extracted with 50 ml EtOAc. The organic phase was washed with 30 ml saturated NaCl. All aqueous phases were combined and extracted with 50 ml EtOAc. The combined organic phases were dried with MgSO4 and evaporated to yield 2.1 g (95%) of the title compound as brownish crystals; MS (m/e): 249.2 (MH+, 100%)

Workup

  1. concentrationThe mixture was concentrated
  2. additiontreated with 20 ml water, 20 ml 2M Na2CO3
  3. extractionextracted with 50 ml EtOAc
  4. washThe organic phase was washed with 30 ml saturated NaCl
  5. extractionextracted with 50 ml EtOAc
  6. dry with materialThe combined organic phases were dried with MgSO4
  7. customevaporated

Sources & evidence

ORD record
ord-5aa903a5e2ec4acfb8c73a9a29fa63fd
Source dataset
uspto-grants-2008_12
Patent number
US07462617B2

Reaction notes

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