HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2374243Generated: October 25, 2026
Piperazine → 1-(4-Cyclopropanesulfonyl-2-fluoro-phenyl)-piperazine
https://huagongshe.com/reaction/2374243
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 4-Cyclopropanesulfonyl-1,2-difluoro-benzene | HCID 69042190 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 1-(4-Cyclopropanesulfonyl-2-fluoro-phenyl)-piperazine | HCID 59853665 | 52.8% |
Reaction Steps
To 4-cyclopropanesulfonyl-1,2-difluoro-benzene (40 mg, 0.18 mmol) in 5 ml N,N-dimethylacetamide was added piperazine (47 mg, 0.55 mmol) and the mixture was heated at 80° C. for 90 min. The mixture was then concentrated in vacuo to afford the tide compound (27 mg, 52%) as a brown solid. MS (ISP): 285.0 MH+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07462617B2 |
|---|
| Source dataset | uspto-grants-2008_12 |
|---|
| ORD ID | ord-f894c9f1e615467f99bd4166c3c5cb22 |
|---|
| Source note | uspto-grants-2008_12 |
|---|
