Piperazine → 1-(4-Cyclopropanesulfonyl-2-fluoro-phenyl)-piperazine

HRID 2374243Notes

Reaction equation

HRID 2374243 reaction equation
[CH:1]1([S:4]([C:7]2[CH:12]=[CH:11][C:10](F)=[C:9]([F:14])[CH:8]=2)(=[O:6])=[O:5])[CH2:3][CH2:2]1.[NH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>CN(C)C(=O)C>[CH:1]1([S:4]([C:7]2[CH:12]=[CH:11][C:10]([N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)=[C:9]([F:14])[CH:8]=2)(=[O:6])=[O:5])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 690421904-Cyclopropanesulfonyl-1,2-difluoro-benzene

Product 1

HCID 598536651-(4-Cyclopropanesulfonyl-2-fluoro-phenyl)-piperazineYield 52.8%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Conditions

Temperature
80 °C

Procedure

To 4-cyclopropanesulfonyl-1,2-difluoro-benzene (40 mg, 0.18 mmol) in 5 ml N,N-dimethylacetamide was added piperazine (47 mg, 0.55 mmol) and the mixture was heated at 80° C. for 90 min. The mixture was then concentrated in vacuo to afford the tide compound (27 mg, 52%) as a brown solid. MS (ISP): 285.0 MH+

Workup

  1. concentrationThe mixture was then concentrated in vacuo

Sources & evidence

ORD record
ord-f894c9f1e615467f99bd4166c3c5cb22
Source dataset
uspto-grants-2008_12
Patent number
US07462617B2

Reaction notes

Loading…