Benzoic acid, 2-chloro-5-[(methylamino)sulfonyl]- → 3-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-chloro-N-methyl-benzenesulfonamide

HRID 2374253Notes

Reaction equation

HRID 2374253 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:14](=[O:16])[CH3:15])[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.[Cl:17][C:18]1[CH:26]=[CH:25][C:24]([S:27](=[O:31])(=[O:30])[NH:28][CH3:29])=[CH:23][C:19]=1[C:20](O)=[O:21]>>[C:14]([C:4]1[CH:5]=[CH:6][C:7]([N:8]2[CH2:13][CH2:12][N:11]([C:20]([C:19]3[CH:23]=[C:24]([S:27]([NH:28][CH3:29])(=[O:31])=[O:30])[CH:25]=[CH:26][C:18]=3[Cl:17])=[O:21])[CH2:10][CH2:9]2)=[C:2]([F:1])[CH:3]=1)(=[O:16])[CH3:15]

Participants

3

Reactant 2

HCID 111724Benzoic acid, 2-chloro-5-[(methylamino)sulfonyl]-HCID 6856101-(3-Fluoro-4-piperazin-1-ylphenyl)ethanone

Product 1

HCID 597936063-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-chloro-N-methyl-benzenesulfonamide

Procedure

The title compound was prepared according to the procedure D described for example 2 from 1-(3-Fluoro-4-piperazin-1-yl-phenyl)-ethanone and 2-Chloro-5-methylsulfamoyl-benzoic acid (CAS: 68901-09-7; BE 620741) (69%, light yellow foam, M−H: 452.1)

Sources & evidence

ORD record
ord-2a8e3826a79e4bec89008f8cf5fdbb82
Source dataset
uspto-grants-2008_12
Patent number
US07462617B2

Reaction notes

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