1-(3-Fluoro-4-piperazin-1-ylphenyl)ethanone → 1-{4-[4-(2-Chloro-5-tetrazol-1-yl-benzoyl)-piperazin-1-yl]-3-fluoro-phenyl}-ethanone

HRID 2374257Notes

Reaction equation

HRID 2374257 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:14](=[O:16])[CH3:15])[CH:5]=[CH:6][C:7]=1[N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.[Cl:17][C:18]1[CH:26]=[CH:25][C:24]([N:27]2[CH:31]=[N:30][N:29]=[N:28]2)=[CH:23][C:19]=1[C:20](O)=[O:21]>>[Cl:17][C:18]1[CH:26]=[CH:25][C:24]([N:27]2[CH:31]=[N:30][N:29]=[N:28]2)=[CH:23][C:19]=1[C:20]([N:11]1[CH2:12][CH2:13][N:8]([C:7]2[CH:6]=[CH:5][C:4]([C:14](=[O:16])[CH3:15])=[CH:3][C:2]=2[F:1])[CH2:9][CH2:10]1)=[O:21]

Participants

3

Reactant 2

HCID 6856101-(3-Fluoro-4-piperazin-1-ylphenyl)ethanoneHCID 11299372-chloro-5-(1H-tetrazol-1-yl)benzoic acid

Product 1

HCID 598536571-{4-[4-(2-Chloro-5-tetrazol-1-yl-benzoyl)-piperazin-1-yl]-3-fluoro-phenyl}-ethanone

Procedure

The title compound was prepared according to the procedure E described for example 2 from 1-(3-Fluoro-4-piperazin-1-yl-phenyl)-ethanone and 2-Chloro-5-tetrazol-1-yl-benzoic acid (CAS: 190270-10-1; commercial) (50%, white solid, M+H: 429.2)

Sources & evidence

ORD record
ord-8c2281e24eee4a4a91728cc443b47990
Source dataset
uspto-grants-2008_12
Patent number
US07462617B2

Reaction notes

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