2,6-Dichloro-3-nitrobenzoic acid → 1-{4-[4-(2,6-Dichloro-3-nitro-benzoyl)-piperazin-1-yl]-3-fluoro-phenyl]-ethanone

HRID 2374258Notes

Reaction equation

HRID 2374258 reaction equation
[Cl:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]([Cl:14])[C:3]=1[C:4]([OH:6])=O.[F:15][C:16]1[CH:17]=[C:18]([C:28](=[O:30])[CH3:29])[CH:19]=[CH:20][C:21]=1[N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>>[Cl:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[C:7]([Cl:14])[C:3]=1[C:4]([N:25]1[CH2:24][CH2:23][N:22]([C:21]2[CH:20]=[CH:19][C:18]([C:28](=[O:30])[CH3:29])=[CH:17][C:16]=2[F:15])[CH2:27][CH2:26]1)=[O:6]

Participants

3

Reactant 2

HCID 3506232,6-Dichloro-3-nitrobenzoic acidHCID 6856101-(3-Fluoro-4-piperazin-1-ylphenyl)ethanone

Product 1

HCID 598536531-{4-[4-(2,6-Dichloro-3-nitro-benzoyl)-piperazin-1-yl]-3-fluoro-phenyl]-ethanone

Procedure

The title compound was prepared according to the procedure E described for Example 9 from 2,6-dichloro-3-nitro-benzoic acid (CAS: 55775-97-8; commercial) and 1-(3-fluoro-4-piperazin-1-yl-phenyl)-ethanone: colourless solid, m.p. 209-211° C., MS (ISP): 440.1 MH+.

Sources & evidence

ORD record
ord-18d0c1f3c60942a7a07ffc9f6e0b41a0
Source dataset
uspto-grants-2008_12
Patent number
US07462617B2

Reaction notes

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