3-Fluoro-4-piperazin-1-yl-benzonitrile → 3-Fluoro-4-[4-(5-methanesulfonyl-2-thiazol-2-yl-benzoyl)-piperazin-1-yl]-benzonitrile
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)[C:5]#[N:6].[CH3:16][S:17]([C:20]1[CH:21]=[CH:22][C:23]([C:29]2[S:30][CH:31]=[CH:32][N:33]=2)=[C:24]([CH:28]=1)[C:25](O)=[O:26])(=[O:19])=[O:18]>>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[N:10]1[CH2:15][CH2:14][N:13]([C:25](=[O:26])[C:24]2[CH:28]=[C:20]([S:17]([CH3:16])(=[O:19])=[O:18])[CH:21]=[CH:22][C:23]=2[C:29]2[S:30][CH:31]=[CH:32][N:33]=2)[CH2:12][CH2:11]1)[C:5]#[N:6]Participants
3
Procedure
The title compound was prepared according to the procedure E described for Example 9 from 3-Fluoro-4-piperazin-1-yl-benzonitrile [182181-38-0] and 5-Methanesulfonyl-2-thiazol-2-yl-benzoic acid (Example O). MS (ISP): 471.4 MH+.
Sources & evidence
- ORD record
- ord-76f6ba3b6b1040b7a26e25a04b942bb1
- Source dataset
- uspto-grants-2008_12
- Patent number
- US07462617B2
Reaction notes
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