1-(2-Fluoro-4-(trifluoromethyl)phenyl)piperazine → [4-(2-Fluoro-4-trifluoromethyl-phenyl)-piperazin-1-yl]-(5-methanesulfonyl-2-thiazol-2-yl-phenyl)-methanone

HRID 2374264Notes

Reaction equation

HRID 2374264 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.[CH3:18][S:19]([C:22]1[CH:23]=[CH:24][C:25]([C:31]2[S:32][CH:33]=[CH:34][N:35]=2)=[C:26]([CH:30]=1)[C:27](O)=[O:28])(=[O:21])=[O:20]>>[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:9])([F:10])[F:11])[CH:5]=[CH:4][C:3]=1[N:12]1[CH2:17][CH2:16][N:15]([C:27]([C:26]2[CH:30]=[C:22]([S:19]([CH3:18])(=[O:21])=[O:20])[CH:23]=[CH:24][C:25]=2[C:31]2[S:32][CH:33]=[CH:34][N:35]=2)=[O:28])[CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 468374951-(2-Fluoro-4-(trifluoromethyl)phenyl)piperazineHCID 598537385-Methanesulfonyl-2-thiazol-2-yl-benzoic acid

Product 1

HCID 59853693[4-(2-Fluoro-4-trifluoromethyl-phenyl)-piperazin-1-yl]-(5-methanesulfonyl-2-thiazol-2-yl-phenyl)-methanone

Procedure

The title compound was prepared according to the procedure E described for Example 9 from 1-(2-Fluoro-4-trifluoromethyl-phenyl)-piperazine (Example F) and 5-Methanesulfonyl-2-thiazol-2-yl-benzoic acid (Example O). MS (ISP): 514.3 MH+.

Sources & evidence

ORD record
ord-a79fbe60716b4dc1b38298e3f31ca663
Source dataset
uspto-grants-2008_12
Patent number
US07462617B2

Reaction notes

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