1-(4-(Trifluoromethoxy)phenyl)piperazine → (4-Methanesulfonyl-biphenyl-2-yl)-[4-(4-trifluoromethoxy-phenyl)-piperazin-1-yl]-methanone

HRID 2374271Notes

Reaction equation

HRID 2374271 reaction equation
[F:1][C:2]([F:17])([F:16])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1.[CH3:18][S:19]([C:22]1[CH:23]=[C:24]([C:34](O)=[O:35])[C:25]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[CH:26][CH:27]=1)(=[O:21])=[O:20]>>[CH3:18][S:19]([C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[C:24]([C:34]([N:13]2[CH2:12][CH2:11][N:10]([C:7]3[CH:8]=[CH:9][C:4]([O:3][C:2]([F:1])([F:16])[F:17])=[CH:5][CH:6]=3)[CH2:15][CH2:14]2)=[O:35])[CH:23]=1)(=[O:20])=[O:21]

Participants

3

Reactant 2

HCID 230811701-(4-(Trifluoromethoxy)phenyl)piperazineHCID 574452544-(methylsulfonyl)-Biphenyl-2-carboxylic acid

Product 1

HCID 59853696(4-Methanesulfonyl-biphenyl-2-yl)-[4-(4-trifluoromethoxy-phenyl)-piperazin-1-yl]-methanone

Procedure

The title compound was prepared according to the procedure E described for Example 9 from 1-(4-Trifluoromethoxy-phenyl)-piperazine [187669-62-1] and 4-Methanesulfonyl-biphenyl-2-carboxylic acid (Example V). MS (ISP): 505.4 MH+.

Sources & evidence

ORD record
ord-a937cb3a796240a4af5b942fac31cff3
Source dataset
uspto-grants-2008_12
Patent number
US07462617B2

Reaction notes

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