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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2374271Generated: October 26, 2026

1-(4-(Trifluoromethoxy)phenyl)piperazine → (4-Methanesulfonyl-biphenyl-2-yl)-[4-(4-trifluoromethoxy-phenyl)-piperazin-1-yl]-methanone

https://huagongshe.com/reaction/2374271

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(4-(Trifluoromethoxy)phenyl)piperazineHCID 23081170—
Reactant4-(methylsulfonyl)-Biphenyl-2-carboxylic acidHCID 57445254—
Product(4-Methanesulfonyl-biphenyl-2-yl)-[4-(4-trifluoromethoxy-phenyl)-piperazin-1-yl]-methanoneHCID 59853696—

Reaction Steps

The title compound was prepared according to the procedure E described for Example 9 from 1-(4-Trifluoromethoxy-phenyl)-piperazine [187669-62-1] and 4-Methanesulfonyl-biphenyl-2-carboxylic acid (Example V). MS (ISP): 505.4 MH+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07462617B2
Source datasetuspto-grants-2008_12
ORD IDord-a937cb3a796240a4af5b942fac31cff3
Source noteuspto-grants-2008_12