2-(Piperazin-1-yl)-5-(trifluoromethyl)pyrimidine → (4-Methanesulfonyl-biphenyl-2-yl)-[4-(5-trifluoromethyl-pyrimidin-2-yl)-piperazin-1-yl]-methanone

HRID 2374275Notes

Reaction equation

HRID 2374275 reaction equation
[N:1]1([C:7]2[N:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][N:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH3:17][S:18]([C:21]1[CH:22]=[C:23]([C:33](O)=[O:34])[C:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:25][CH:26]=1)(=[O:20])=[O:19]>>[CH3:17][S:18]([C:21]1[CH:26]=[CH:25][C:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[C:23]([C:33]([N:4]2[CH2:5][CH2:6][N:1]([C:7]3[N:8]=[CH:9][C:10]([C:13]([F:14])([F:16])[F:15])=[CH:11][N:12]=3)[CH2:2][CH2:3]2)=[O:34])[CH:22]=1)(=[O:19])=[O:20]

Participants

3

Reactant 2

HCID 163147972-(Piperazin-1-yl)-5-(trifluoromethyl)pyrimidineHCID 574452544-(methylsulfonyl)-Biphenyl-2-carboxylic acid

Product 1

HCID 59853648(4-Methanesulfonyl-biphenyl-2-yl)-[4-(5-trifluoromethyl-pyrimidin-2-yl)-piperazin-1-yl]-methanone

Procedure

The title compound was prepared according to the procedure E described for Example 9 from 2-Piperazin-1-yl-5-trifluoromethyl-pyrimidine (Example AE) and 4-Methanesulfonyl-biphenyl-2-carboxylic acid (Example V). MS (ISP): 431.1 MH+.

Sources & evidence

ORD record
ord-da170cf44096452ea704c31f73c75063
Source dataset
uspto-grants-2008_12
Patent number
US07462617B2

Reaction notes

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