Potassium Carbonate → HCID 59853652, compound

HRID 2374279Notes

Reaction equation

HRID 2374279 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([C:29]#[C:30][Si](C)(C)C)=[C:9]([C:11]([N:13]2[CH2:18][CH2:17][N:16]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=3)[CH2:15][CH2:14]2)=[O:12])[CH:10]=1)(=[O:4])=[O:3].C([O-])([O-])=O.[K+].[K+]>CO>[C:29]([C:8]1[CH:7]=[CH:6][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:10][C:9]=1[C:11]([N:13]1[CH2:18][CH2:17][N:16]([C:19]2[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=2)[CH2:15][CH2:14]1)=[O:12])#[CH:30]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 59853658[5-(Methylsulfonyl)-2-[2-(trimethylsilyl)ethynyl]phenyl][4-[4-(trifluoromethyl)phenyl]-1-piperazinyl]methanone

Product 1

HCID 59853652HCID 59853652, compoundYield 42%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of (5-Methanesulfonyl-2-trimethylsilanylethynyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone, Example L (45 mg, 0.0885 mmol) in methanol (0.5 ml) was added K2CO3 (4 mg, 0.0289 mmol). The mixture was stirred at rt for 1 hour. The solvent was removed in vacuo. The residue was purified on SiO2 ,Eluent: Heptane/AcOEt 0%,-40% (10 minutes), then 40% (5 minutes) to provide the title compound (16 mg, 42%, yellow foam), M+H=437.1

Workup

  1. customThe solvent was removed in vacuo
  2. customThe residue was purified on SiO2

Sources & evidence

ORD record
ord-47f5dbb52ff54eb08ce9a9bdbe153750
Source dataset
uspto-grants-2008_12
Patent number
US07462617B2

Reaction notes

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