1-(3-Fluoro-4-piperazin-1-ylphenyl)ethanone → 2-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-nitro-benzoic acid methyl ester

HRID 2374283Notes

Reaction equation

HRID 2374283 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:14]([O-:16])=O)[C:7](=[CH:12][CH:13]=1)[C:8]([O:10][CH3:11])=[O:9])([O-:3])=[O:2].[F:17][C:18]1[CH:19]=[C:20]([C:30](=[O:32])[CH3:31])[CH:21]=[CH:22][C:23]=1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>>[CH3:11][O:10][C:8](=[O:9])[C:7]1[CH:12]=[CH:13][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][C:6]=1[C:14]([N:27]1[CH2:26][CH2:25][N:24]([C:23]2[CH:22]=[CH:21][C:20]([C:30](=[O:32])[CH3:31])=[CH:19][C:18]=2[F:17])[CH2:29][CH2:28]1)=[O:16]

Participants

3

Reactant 2

HCID 6856101-(3-Fluoro-4-piperazin-1-ylphenyl)ethanoneHCID 19595681Methyl 4-nitrophthalate

Product 1

HCID 112933072-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-nitro-benzoic acid methyl ester

Procedure

Following procedure D, the title compound is prepared by reaction of methyl 4-nitrophthalate [90072-77-8] with 1-(3fluoro-4-piperazin-1-yl-phenyl)-ethanone (m.p. 189-191° C., MS (ISP): 429.4 M+H+).

Sources & evidence

ORD record
ord-cb5ab680dc964eb2a4d956a52a7b6c71
Source dataset
uspto-grants-2008_12
Patent number
US07462617B2

Reaction notes

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