Methyl Acrylate → HCID 59853692, compound

HRID 2374290Notes

Reaction equation

HRID 2374290 reaction equation
I[C:2]1[CH:23]=[CH:22][C:21]([S:24]([CH3:27])(=[O:26])=[O:25])=[CH:20][C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)=[O:5].[C:28]([O:32][CH3:33])(=[O:31])[CH:29]=[CH2:30]>C1CCCCC1.C(OCC)(=O)C>[CH3:33][O:32][C:28](=[O:31])/[CH:29]=[CH:30]/[C:2]1[CH:23]=[CH:22][C:21]([S:24]([CH3:27])(=[O:26])=[O:25])=[CH:20][C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)=[O:5]

Participants

4

Reactant 2

HCID 7294Methyl AcrylateHCID 59853727HCID 59853727, compound

Product 1

HCID 59853692HCID 59853692, compound

Reagents, catalysts & solvents 1

HCID 21867204Cyclohexane ethylacetateSolvent

Procedure

Prepared in analogy to example 139 from 4-[4-(2-Iodo-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrile (Example AG) and methyl acrylate. Chromatography (SiO2; cyclohexane/ethyl acetate 3:7) yields the title compound as a slightly yellow solid (M+H+: 454.3)

Sources & evidence

ORD record
ord-af99d427b6d5493bb4c155099a8902b8
Source dataset
uspto-grants-2008_12
Patent number
US07462617B2

Reaction notes

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