Trifluoroacetohydrazide → HCID 178446280, compound

HRID 2374322Notes

Reaction equation

HRID 2374322 reaction equation
[CH2:1]([NH:6][C:7]1[N:8]=[CH:9][NH:10][C:11]=1[C:12](SC)=[NH:13])[CH2:2][CH2:3][CH2:4][CH3:5].[F:16][C:17]([F:23])([F:22])[C:18]([NH:20][NH2:21])=O>C(O)C>[CH2:1]([NH:6][C:7]1[N:8]=[CH:9][NH:10][C:11]=1[C:12]1[NH:21][N:20]=[C:18]([C:17]([F:23])([F:22])[F:16])[N:13]=1)[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 229753TrifluoroacetohydrazideHCID 135984704methyl 4-(pentylamino)-1H-imidazole-5-carbimidothioate

Product 1

HCID 178446280HCID 178446280, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The mixture of methyl 4-(pentylamino)-1H-imidazole-5-carbimidothioate (0.53 g, 2.4 mmol) and trifluoroacetic acid hydrazide (0.45 g, 3.5 mmol) in ethanol (10 mL) was refluxed overnight. The reaction mixture was concentrated to yield the product as slightly green viscous oil. LCMS calculated for C11H16F3N6(M+H): 289.1; found: 289.1.

Workup

  1. temperaturewas refluxed overnight
  2. concentrationThe reaction mixture was concentrated
  3. customto yield the product as slightly green viscous oil

Sources & evidence

ORD record
ord-aff303fd66c948cc8dda709e1a4b0f29
Source dataset
uspto-grants-2008_12
Patent number
US07462624B2

Reaction notes

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