Trifluoroacetic acid → HCID 178448706, compound

HRID 2374338Notes

Reaction equation

HRID 2374338 reaction equation
[CH2:1]([N:5]1[C:13]2[N:12](C3CCCCO3)[CH:11]=[N:10][C:9]=2[C:8]2=[N:20][N:21]=[CH:22][N:7]2[C:6]1=[O:23])[CH:2]([CH3:4])[CH3:3].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:1]([N:5]1[C:13]2[NH:12][CH:11]=[N:10][C:9]=2[C:8]2=[N:20][N:21]=[CH:22][N:7]2[C:6]1=[O:23])[CH:2]([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59853841HCID 59853841, compound

Product 1

HCID 178448706HCID 178448706, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 6-isobutyl-7-(tetrahydro-2H-pyran-2-yl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-i]purin-5-one (20 mg, 0.06 mmol) in methylene chloride (0.8 mL) was added TFA (0.1 mL, 1 mmol) dropwise. After stirring at room temperature for 30 minutes, the reaction mixture was concentrated to give the crude product which was used for next step without further purification. LCMS calculated for C10H13N6O (M+H): 233.1; found: 233.1.

Workup

  1. concentrationthe reaction mixture was concentrated

Sources & evidence

ORD record
ord-c8a47d426f16449cb88ee98574780332
Source dataset
uspto-grants-2008_12
Patent number
US07462624B2

Reaction notes

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