4-Chloro-7-(2-chloroethoxy)-6-methoxyquinazoline → HCID 68550848, compound

HRID 2374422Notes

Reaction equation

HRID 2374422 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH2:15][CH2:16][Cl:17])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:18][C:19]1[C:24]([Cl:25])=[CH:23][N:22]=[C:21]2[O:26][CH2:27][O:28][C:20]=12>>[Cl:17][CH2:16][CH2:15][O:14][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH:18][C:19]3[C:24]([Cl:25])=[CH:23][N:22]=[C:21]4[O:26][CH2:27][O:28][C:20]=34)=[N:3][CH:4]=[N:5]2)=[CH:10][C:9]=1[O:12][CH3:13]

Participants

3

Reactant 2

HCID 596829074-Chloro-7-(2-chloroethoxy)-6-methoxyquinazolineHCID 685486516-chloro-2H-[1,3]dioxolo[4,5-b]pyridin-7-amine

Product 1

HCID 68550848HCID 68550848, compoundYield 92%

Procedure

Using an analogous procedure to that described in Example 1, 4-chloro-7-(2-chloroethoxy)6-methoxyquinazoline was reacted with 4-amino-5-chloro-2,3-methylenedioxypyridine to give the title compound in 92% yield; NMR Spectrum: (DMSOd6 and CD3CO2D) 4.05 (s, 3H), 4.1 (t, 2H), 4.55 (t, 2H), 6.3 (s, 2H), 7.4 (s, 1H), 7.9 (s, 1H), 8.15 (s, 1H), 8.95 (s, 1H); Mass Spectrum: M+H+ 409 and 411.

Sources & evidence

ORD record
ord-053daa8e4c6d4637b4deefda0dac4938
Source dataset
uspto-grants-2008_12
Patent number
US07462623B2

Reaction notes

Loading…