6-chloro-2H-[1,3]dioxolo[4,5-b]pyridin-7-amine → HCID 68545021, compound

HRID 2374428Notes

Reaction equation

HRID 2374428 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:19][CH2:20][CH2:21][CH2:22][Cl:23])=[CH:9][C:10]=2[O:12][CH:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[N:5]=[CH:4][N:3]=1.[NH2:24][C:25]1[C:30]([Cl:31])=[CH:29][N:28]=[C:27]2[O:32][CH2:33][O:34][C:26]=12>>[Cl:31][C:30]1[C:25]([NH:24][C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:19][CH2:20][CH2:21][CH2:22][Cl:23])=[CH:9][C:10]=3[O:12][CH:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)[N:5]=[CH:4][N:3]=2)=[C:26]2[O:34][CH2:33][O:32][C:27]2=[N:28][CH:29]=1

Participants

3

Reactant 2

HCID 685486516-chloro-2H-[1,3]dioxolo[4,5-b]pyridin-7-amineHCID 866052974-Chloro-7-(3-chloropropoxy)-5-[(tetrahydro-2H-pyran-4-yl)oxy]quinazoline

Product 1

HCID 68545021HCID 68545021, compoundYield 78%

Procedure

Using an analogous procedure to that described in Example 1, 4-chloro-7-(3-chloropropoxy)-5-tetrahydropyran-4-yloxyquinazoline was reacted with 4-amino-5-chloro-2,3-methylenedioxypyridine to give the title compound in 78% yield; Mass Spectrum: M+H+ 493 and 495.

Sources & evidence

ORD record
ord-cd2f8381d384475fbe30d1250cea0ca2
Source dataset
uspto-grants-2008_12
Patent number
US07462623B2

Reaction notes

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