4-Chloro-7-(3-chloropropoxy)quinazoline → HCID 68545232, compound

HRID 2374430Notes

Reaction equation

HRID 2374430 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH2:13][CH2:14][CH2:15][Cl:16])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:17][C:18]1[C:23]([Cl:24])=[CH:22][N:21]=[C:20]2[O:25][CH2:26][O:27][C:19]=12>>[Cl:24][C:23]1[C:18]([NH:17][C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:12][CH2:13][CH2:14][CH2:15][Cl:16])=[CH:9][CH:10]=3)[N:5]=[CH:4][N:3]=2)=[C:19]2[O:27][CH2:26][O:25][C:20]2=[N:21][CH:22]=1

Participants

3

Reactant 2

HCID 162215144-Chloro-7-(3-chloropropoxy)quinazolineHCID 685486516-chloro-2H-[1,3]dioxolo[4,5-b]pyridin-7-amine

Product 1

HCID 68545232HCID 68545232, compoundYield 89%

Procedure

Using an analogous procedure to that described in Example 1, 4-chloro-7-(3-chloropropoxy)quinazoline was reacted with 4-amino-5-chloro-2,3-methylenedioxypyridine to give the title compound in 89% yield; NMR Spectrum: (DMSOd6 and CF3CO2D) 2.25 (m, 2H), 3.8 (t, 2H), 4.35 (t, 2H), 6.25 (s, 2H), 7.35 (s, 1H), 7.6 (d, 1H), 7.9 (s, 1H), 8.7 (d, 1H), 9.0 (s, 1H).

Sources & evidence

ORD record
ord-4af11563eb124daa9a447614afbcdb62
Source dataset
uspto-grants-2008_12
Patent number
US07462623B2

Reaction notes

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