Trifluoroacetic acid → HCID 11328533, compound

HRID 2374450Notes

Reaction equation

HRID 2374450 reaction equation
C([O:5][C:6](=[O:37])[CH2:7][CH2:8][N:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([CH2:19][O:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)=[C:23]([C:33]([F:36])([F:35])[F:34])[CH:22]=3)[CH:15]=2)[CH2:10]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:36][C:33]([F:34])([F:35])[C:23]1[CH:22]=[C:21]([O:20][CH2:19][C:14]2[CH:15]=[C:16]3[C:11](=[CH:12][CH:13]=2)[CH2:10][N:9]([CH2:8][CH2:7][C:6]([OH:37])=[O:5])[CH2:18][CH2:17]3)[CH:26]=[CH:25][C:24]=1[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69171162HCID 69171162, compound

Product 1

HCID 11328533HCID 11328533, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 3-[6-(2-trifluoromethyl-biphenyl-4-yloxymethyl)-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid tert-butyl ester (35 mg, 0.068 mmol) in CH2Cl2 (1 mL) is added TFA (1 mL). The mixture is stirred at room temperature for an hour. All the solvents are evaporated. The mixture is purified by reverse phase preparative LC/MS to give 3-[6-(2-trifluoromethyl-biphenyl-4-yloxymethyl)-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid:

Workup

  1. customAll the solvents are evaporated
  2. customThe mixture is purified by reverse phase preparative LC/MS

Sources & evidence

ORD record
ord-d2c5a2c66cd54a28bc847a57fb09cfbd
Source dataset
uspto-grants-2008_12
Patent number
US07462629B2

Reaction notes

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