反应详情

温度

140 °C

To a solution of 4-bromo-3,5-dimethylphenol (3 g) in N-methyl-pyrrolidone (10 mL) is slowly added Cs2CO3 (9.7 g) and tetrahydro-2H-pyran-4-yl methanesulfonate (5.4 g). The mixture is heated for 3 hours at 140° C. After cooling to room temperature the mixture is partitioned between saturated aqueous Na2CO3 solution and ethyl acetate. The aqueous phase is extracted with ethyl acetate and the combined organic phases are dried (MgSO4). The solvents are evaporated and the residue is purified by HPLC on reversed phase to give the title compound. Yield: 1.2 g; LC (method 4): tR=1.83 min.

1. temperatureAfter cooling to room temperature the mixture
2. customis partitioned between saturated aqueous Na2CO3 solution and ethyl acetate
3. extractionThe aqueous phase is extracted with ethyl acetate
4. dry with materialthe combined organic phases are dried (MgSO4)
5. customThe solvents are evaporated
6. customthe residue is purified by HPLC on reversed phase