Cyclopropanecarbonyl chloride → HCID 178456526, compound

HRID 2374521Notes

Reaction equation

[NH2:1][C:2]1[C:3]([C:7]2[NH:24][C:10]3=[CH:11][C:12]4[C:13]([CH3:23])([CH3:22])[C:14](=[O:21])[N:15]([CH:18]([CH3:20])[CH3:19])[C:16]=4[CH:17]=[C:9]3[N:8]=2)=[N:4][NH:5][CH:6]=1.[CH:25]1([C:28](Cl)=[O:29])[CH2:27][CH2:26]1>>[CH:18]([N:15]1[C:16]2[CH:17]=[C:9]3[N:8]=[C:7]([C:3]4[C:2]([NH:1][C:28]([CH:25]5[CH2:27][CH2:26]5)=[O:29])=[CH:6][NH:5][N:4]=4)[NH:24][C:10]3=[CH:11][C:12]=2[C:13]([CH3:22])([CH3:23])[C:14]1=[O:21])([CH3:19])[CH3:20]

Participants

Reactant 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 178456528HCID 178456528, compound

Product 1

HCID 178456526HCID 178456526, compound

Procedure

Cyclopropanecarboxylic acid[3-(5-isopropyl-7,7-dimethyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-amide was prepared using 2-(4-amino-1H-pyrazol-3-yl)-5-isopropyl-7,7-dimethyl-5,7-dihydro-1H-imidazo[4,5-f]indol-6-one (325 mg, 0.90 mmol) and cyclopropanecarbonyl chloride (92 μl, 0.99 mmol). The title compound was obtained as dark green powder (85 mg, 22%).

Workup

customCyclopropanecarboxylic acid[3-(5-isopropyl-7,7-dimethyl-6-oxo-1,5,6,7-tetrahydro-imidazo[4,5-f]indol-2-yl)-1H-pyrazol-4-yl]-amide was prepared

Sources & evidence

ORD record: ord-a16544938718457396225707f274fd7b
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07462639B2

Reaction notes

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