反应详情

温度

50 °C

Cs2CO3 (850 mg) is added to a solution of 2-(2-oxopyrrolidin-1-yl)ethyl 4-methylbenzenesulfonate (390 mg) and 4-bromo-3,5-dimethylphenol (200 mg) in N,N-dimethylformamide (4 mL). The mixture is heated to 50° C. for 12 hours and partitioned between diethylether and saturated aqueous NH4Cl solution. The organic phase is dried (MgSO4) and concentrated. The residue is chromatographed on silica gel (ethyl acetate) to give the title compound. Yield: 210 mg; Mass spectrum (ESI+): m/z=312 [M+H]+.

1. custompartitioned between diethylether and saturated aqueous NH4Cl solution
2. dry with materialThe organic phase is dried (MgSO4)
3. concentrationconcentrated
4. customThe residue is chromatographed on silica gel (ethyl acetate)