HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Bromo-3,5-dimethylphenyl)trimethylsilane → 4-(2,6-Dimethyl-4-(trimethylsilyl)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Bromo-3,5-dimethylphenyl)trimethylsilane | HCID 86697146 | — |
| Reactant | 7-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-one | HCID 86697148 | — |
| Product | 4-(2,6-Dimethyl-4-(trimethylsilyl)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-one | HCID 86697147 | — |
Reaction Steps
The title compound is prepared from 7-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-one and (4-bromo-3,5-dimethylphenyl)trimethylsilane following a procedure analogous to that described in Step 5 of Intermediate 1. LC (method 8): tR=0.89 min; Mass spectrum (ESI+): m/z=327 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642585B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-87bf6dbcbfc94834885e4d1e7fb020a1 |
| Source note | uspto-grants-2014_02 |