Hydrogen chloride-ethyl acetate → HCID 68421306, compound

HRID 2374851Notes

Reaction equation

HRID 2374851 reaction equation
[CH:1]1[C:11]2[CH:10]=[CH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[C:16]3[CH2:21][CH2:20][N:19]([C:22](=[O:40])[C@@H:23]([NH:32]C(=O)OC(C)(C)C)[CH2:24][NH:25][C:26](=[O:31])[C:27]([CH3:30])([CH3:29])[CH3:28])[CH2:18][CH2:17]3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[ClH:41].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:41].[NH2:32][C@H:23]([C:22]([N:19]1[CH2:18][CH2:17][C:16](=[C:6]2[C:5]3[CH:4]=[CH:3][CH:2]=[CH:1][C:11]=3[CH:10]=[CH:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]2=3)[CH2:21][CH2:20]1)=[O:40])[CH2:24][NH:25][C:26](=[O:31])[C:27]([CH3:30])([CH3:29])[CH3:28]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86594134HCID 86594134, compound

Product 1

HCID 68421306HCID 68421306, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1.40 g (2.57 mmol) of the compound obtained in step 1 described above was dissolved in 12 ml of ethyl acetate. 10 ml of 4 N hydrochloric acid/ethyl acetate was added to the obtained solution under cooling with ice. The temperature was gradually elevated to room temperature. After stirring for 3.5 hours, the solvent was evaporated under reduced pressure to obtain the title compound.

Workup

  1. temperatureunder cooling with ice
  2. customwas gradually elevated to room temperature
  3. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-551172fd65c64dfb8a6363dec927ad9b
Source dataset
uspto-grants-2008_12
Patent number
US07462630B2

Reaction notes

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