反应详情

In a similar manner as described for Intermediate 10, 6-(1-aminoethyl)-N-(3,4,5-trimethoxyphenyl)-1,2,4-triazin-3-amine (Intermediate 9) (0.30 g, 1.0 mmol), triethylamine (0.28 mL, 2.0 mmol) and 4-fluorobenzoyl chloride (0.16 g, 1.0 mmol) in dichloromethane (10 mL) gave 4-fluoro-N-(1-{3-[(3,4,5-trimethoxyphenyl)amino]-1,2,4-triazin-6-yl}ethyl)benzamide (0.32 g) as a white solid. MS m/z 428 (M+1).