1,1-Dioxo-1lambda6-thiolane-3-carboxylic acid → 3-(Hydroxymethyl)-1lambda6-thiolane-1,1-dione

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

1,1-Dioxo-tetrahydrothiophene-3-carboxylic acid (300 mg) is dissolved in dry tetrahydrofuran (10 mL). The reaction mixture is cooled to 0° C. and borane tetrahydrofuran complex (2 mL) is added dropwise. After stirring for 1 hour at 0° C., the mixture is concentrated under vacuum, partitioned between dichloromethane and water. The organic phase is dried (MgSO4) and concentrated to give the title compound. Yield: 250 mg.

Herkunft & Nachweise