反应详情

温度

0 °C

1,1-Dioxo-tetrahydrothiophene-3-carboxylic acid (300 mg) is dissolved in dry tetrahydrofuran (10 mL). The reaction mixture is cooled to 0° C. and borane tetrahydrofuran complex (2 mL) is added dropwise. After stirring for 1 hour at 0° C., the mixture is concentrated under vacuum, partitioned between dichloromethane and water. The organic phase is dried (MgSO4) and concentrated to give the title compound. Yield: 250 mg.

1. additionborane tetrahydrofuran complex (2 mL) is added dropwise
2. concentrationthe mixture is concentrated under vacuum
3. custompartitioned between dichloromethane and water
4. dry with materialThe organic phase is dried (MgSO4)
5. concentrationconcentrated