反应详情

In a similar manner as described for Example 9, 3-bromo-N-[1-(3-{[5-(ethylsulfonyl)-2-methoxyphenyl]amino}-1,2,4-triazin-6-yl)ethyl]benzamide (Intermediate 23) (0.11 g, 0.20 mmol) and 1,2,4-triazole (83 mg, 1.2 mmol) in pyridine (2 mL) and phosphorus oxychloride (0.056 mL, 0.6 mmol) gave 7-(3-bromophenyl)-N-[5-(ethylsulfonyl)-2-methoxyphenyl]-5-methylimidazo[5,1-f][1,2,4]triazin-2-amine (0.028 g) as a yellow solid. 1H NMR (CDCl3): δ8.89 (d, J=2.2 Hz, 1H), 8.85 (s, 1H), 8.69-8.60 (m, 1H), 8.43 (dd, J=1.8, 1.8 Hz, 1H), 7.81-7.75 (m, 2H), 7.63 (dd, J=8.5, 2.3 Hz, 1H), 7.58 (ddd, J=7.9, 2.0, 1.0 Hz, 1H), 7.04 (d, J=8.6 Hz, 1H), 4.04 (s, 3H), 3.06 (q, J=7.4 Hz, 2H), 2.63 (s, 3H), 1.23 (t, J=7.4 Hz, 3H). MS m/z 502, 504 (M+1, M+3).