Cyclohexanecarbonyl chloride → HCID 58711957, compound

HRID 2374996Notes

Reaction equation

HRID 2374996 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]2[N:11]=[N:12][C:13]([CH:16]([NH:18][C:19]([CH:21]3[CH2:23][CH2:22]3)=[O:20])[CH3:17])=[CH:14][N:15]=2)=[CH:5][CH:4]=1.N[CH:25]([C:27]1N=NC(NC2C=CC(OC)=CC=2)=NC=1)[CH3:26].C1(C(Cl)=O)CCCCC1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]2[N:11]=[N:12][C:13]([CH:16]([NH:18][C:19]([CH:21]3[CH2:23][CH2:22][CH2:27][CH2:25][CH2:26]3)=[O:20])[CH3:17])=[CH:14][N:15]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 75938Cyclohexanecarbonyl chlorideHCID 58711982HCID 58711982, compoundHCID 587119996-(1-aminoethyl)-N-[4-(methyloxy)phenyl]-1,2,4-triazin-3-amine2×

Product 1

HCID 58711957HCID 58711957, compound

Procedure

In a similar manner as described for Intermediate 62, using 6-(1-aminoethyl)-N-[4-(methyloxy)phenyl]-1,2,4-triazin-3-amine (Intermediate 47) (100 mg, 0.41 mmol), and cyclohexanecarbonyl chloride (0.065 mL, 0.45 mmol) to afford N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]cyclohexane-carboxamide (90 mg) as a yellow solid. MS m/z 356 (M+1).

Sources & evidence

ORD record
ord-123c65ee7b4c440f96f779b2932a3cd7
Source dataset
uspto-grants-2008_12
Patent number
US07462614B2

Reaction notes

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