反应详情

(S)-3-Bromo-2-methyl-1-propanol (150 mg), 4-bromo-3,5-dimethylphenol (98.5 mg) and potassium carbonate are stirred in 5 mL of acetonitrile at 80° C. for 4 h. The reaction mixture is cooled to room temperature, water is added and the reaction mixture is extracted with diethyl ether. The organic phase is separated, dried over sodium sulfate and concentrated under vacuum to give a solid, used in the next step without further purification. Yield: 130 mg.

1. extractionthe reaction mixture is extracted with diethyl ether
2. customThe organic phase is separated
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated under vacuum
5. customto give a solid
6. customused in the next step without further purification