Phenylacetyl chloride → HCID 58711998, compound

HRID 2375001Notes

Reaction equation

HRID 2375001 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]2[N:11]=[N:12][C:13]([CH:16]([NH:18][C:19]([C:21]3O[CH:23]=[CH:24][CH:25]=3)=[O:20])[CH3:17])=[CH:14][N:15]=2)=[CH:5][CH:4]=1.N[CH:27]([C:29]1N=NC(NC2C=CC(OC)=CC=2)=NC=1)[CH3:28].C1(CC(Cl)=O)C=CC=CC=1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]2[N:11]=[N:12][C:13]([CH:16]([NH:18][C:19](=[O:20])[CH2:21][C:25]3[CH:24]=[CH:23][CH:29]=[CH:27][CH:28]=3)[CH3:17])=[CH:14][N:15]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 7679Phenylacetyl chlorideHCID 58711967HCID 58711967, compoundHCID 587119996-(1-aminoethyl)-N-[4-(methyloxy)phenyl]-1,2,4-triazin-3-amine2×

Product 1

HCID 58711998HCID 58711998, compound

Procedure

In a similar manner as described for Intermediate 59, using 6-(1-aminoethyl)-N-[4-(methyloxy)phenyl]-1,2,4-triazin-3-amine (Intermediate 47) (100 mg, 0.41 mmol), and phenylacetyl chloride (0.059 mL, 0.45 mmol) to afford N-[1-(3-{[4-(methyloxy)phenyl]amino}-1,2,4-triazin-6-yl)ethyl]-2-phenylacetamide (50 mg) as a yellow solid. MS m/z 364 (M+1).

Sources & evidence

ORD record
ord-73fc13287aa34e2e84bfa3202f2202d3
Source dataset
uspto-grants-2008_12
Patent number
US07462614B2

Reaction notes

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