Trifluoroacetic acid → HCID 137241994, compound

HRID 2375082Notes

Reaction equation

HRID 2375082 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][C:16](=[O:38])[NH:17][C:18]2[CH:19]=[C:20]3[C:36](=[O:37])[NH:35][N:34]=[CH:33][C:22]4=[C:23]([C:27]5[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=5)[NH:24][C:25]([CH:26]=2)=[C:21]34)[CH2:10][CH2:9]1)=O)(C)(C)C.[C:39]([OH:45])([C:41]([F:44])([F:43])[F:42])=[O:40]>C(Cl)Cl>[F:42][C:41]([F:44])([F:43])[C:39]([OH:45])=[O:40].[O:37]=[C:36]1[C:20]2[C:21]3[C:22](=[C:23]([C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=4)[NH:24][C:25]=3[CH:26]=[C:18]([NH:17][C:16](=[O:38])[CH2:15][CH2:14][CH:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[CH:19]=2)[CH:33]=[N:34][NH:35]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 136181642HCID 136181642, compound

Product 1

HCID 137241994HCID 137241994, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Preparation of example 92 from title compound of Example 88 (52 mg, 0.101 mmol) and 45% TFA in CH2Cl2 (1 mL) was carried out analogously to Example 20. Isolation, also in an analogous manner, afforded the title compound (50 mg, 0.084 mmol) as a yellow powder in 82% yield.

Sources & evidence

ORD record
ord-5476c13440eb4b1bb390abe35322ebcf
Source dataset
uspto-grants-2008_12
Patent number
US07462713B2

Reaction notes

Loading…