Hydrochloric Acid → HCID 136401843, compound

HRID 2375108Notes

Reaction equation

HRID 2375108 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][C@@H:12]([NH:30]C(=O)OC(C)(C)C)[C:13](=[O:29])[NH:14][C:15]1[CH:16]=[C:17]2[C:27](=[O:28])[NH:26][N:25]=[CH:24][C:19]3=[CH:20][NH:21][C:22]([CH:23]=1)=[C:18]23.[ClH:38]>O1CCOCC1>[ClH:38].[NH2:30][C@H:12]([CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)[C:13]([NH:14][C:15]1[CH:16]=[C:17]2[C:27](=[O:28])[NH:26][N:25]=[CH:24][C:19]3=[CH:20][NH:21][C:22]([CH:23]=1)=[C:18]23)=[O:29]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136181624HCID 136181624, compound

Product 1

HCID 136401843HCID 136401843, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Preparation of example 179 from the title compound of Example 158 (57 mg, 0.115 mmol) and 4M HCl in dioxane (10 mL) was carried out analogously to Example 91. Isolation, also in an analogous manner afforded the title compound (48 mg, 0.111 mmol) as an orange/yellow powder in 97% yield.

Sources & evidence

ORD record
ord-603e7e2737ee47f5bdad3b2d99d59cab
Source dataset
uspto-grants-2008_12
Patent number
US07462713B2

Reaction notes

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