HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 136181622, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Boc-D-homophenylalanine | HCID 2755954 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 178424012 | HCID 178424012 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 136181622 | HCID 136181622 | — |
Reaction Steps
To a solution of (2R)-2-[(tert-butoxycarbonyl)amino]-4-phenylbutanoic acid and 2-(6-methylpyridin-3-yl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-aminium chloride 267(b) in 8 mL of anhydrous dimethylformamide containing triethylamine (0.3 mL, 2.3 mmol) stirred in an ice/water bath was added HATU (244 mg, 0.64 mmol), portion-wise. The mixture was then stirred overnight at room temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07462713B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-08f42fd800844b269d9cf17aeda4e6a8 |
| Source note | uspto-grants-2008_12 |