Triethylamine → HCID 136181622, compound

HRID 2375120Notes

Reaction equation

HRID 2375120 reaction equation
[C:1]([O:5][C:6]([NH:8][C@H:9]([CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:10]([OH:12])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl-].[CH3:22][C:23]1[N:28]=[CH:27][C:26]([C:29]2[NH:30][C:31]3[CH:32]=[C:33]([NH3+:43])[CH:34]=[C:35]4[C:41](=[O:42])[NH:40][N:39]=[CH:38][C:37]=2[C:36]=34)=[CH:25][CH:24]=1.C(N(CC)CC)C.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>CN(C)C=O>[CH3:22][C:23]1[N:28]=[CH:27][C:26]([C:29]2[NH:30][C:31]3[CH:32]=[C:33]([NH:43][C:10]([C@H:9]([NH:8][C:6](=[O:7])[O:5][C:1]([CH3:2])([CH3:3])[CH3:4])[CH2:13][CH2:14][C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)=[O:12])[CH:34]=[C:35]4[C:41](=[O:42])[NH:40][N:39]=[CH:38][C:37]=2[C:36]=34)=[CH:25][CH:24]=1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 2755954Boc-D-homophenylalanineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 178424012HCID 178424012, compound

Product 1

HCID 136181622HCID 136181622, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of (2R)-2-[(tert-butoxycarbonyl)amino]-4-phenylbutanoic acid and 2-(6-methylpyridin-3-yl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-aminium chloride 267(b) in 8 mL of anhydrous dimethylformamide containing triethylamine (0.3 mL, 2.3 mmol) stirred in an ice/water bath was added HATU (244 mg, 0.64 mmol), portion-wise. The mixture was then stirred overnight at room temperature.

Workup

  1. stirringThe mixture was then stirred overnight at room temperature

Sources & evidence

ORD record
ord-08f42fd800844b269d9cf17aeda4e6a8
Source dataset
uspto-grants-2008_12
Patent number
US07462713B2

Reaction notes

Loading…