Hydrochloric Acid → HCID 178424012, compound

HRID 2375121Notes

Reaction equation

C(OC(=O)[NH:7][C:8]1[CH:9]=[C:10]2[C:27](=[O:28])[NH:26][N:25]=[CH:24][C:12]3=[C:13]([C:17]4[CH:18]=[N:19][C:20]([CH3:23])=[CH:21][CH:22]=4)[NH:14][C:15]([CH:16]=1)=[C:11]23)(C)(C)C.[ClH:30]>>[Cl-:30].[CH3:23][C:20]1[N:19]=[CH:18][C:17]([C:13]2[NH:14][C:15]3[CH:16]=[C:8]([NH3+:7])[CH:9]=[C:10]4[C:27](=[O:28])[NH:26][N:25]=[CH:24][C:12]=2[C:11]=34)=[CH:22][CH:21]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 136181665HCID 136181665, compound

Product 1

HCID 178424012HCID 178424012, compound

Procedure

Compound 267 (b) was obtained by reacting tert-butyl[2-(6-methylpyridin-3-yl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]carbamate with 4M HCl in dioxanes. Product 267(b) was isolated in quantitative yield as an orange powder after filtration and ether rinse and was carried on without further purification.

Sources & evidence

ORD record: ord-c518ac1ed4094737b1a9a2ed6f88f539
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07462713B2

Reaction notes

Loading…