反应详情

A stirred mixture of 9,10-dihydro-4H-3a, 5,9-triaza-benzo[f]azulene of Step D (0.54 mmol), 4-phenylbenzoylchloride (1.08 mmol) and triethylamine (1.08 mmol) in toluene was refluxed under nitrogen for 72 hours. The reaction was cooled and the solvent removed in vacuo. Chromatography of the residue over silica gel Merck-60 with a solvent gradient from 5 to 20% ethyl acetate in hexane provided the title compound as a tan solid.

1. temperaturewas refluxed under nitrogen for 72 hours
2. temperatureThe reaction was cooled
3. customthe solvent removed in vacuo