HRID237524

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(Br)ccc(F)c43)ccc21

HCID86697103

未命名化合物

HCID86697188

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(-c5c(C)cc(C(=O)NCC(C)(C)O)cc5C)ccc(F)c43)ccc21

HCID86697187

未命名化合物

PROCEDURE

实验过程

The title compound is prepared following a procedure analogous to that described in Step 5 in the preparation of Intermediate 1, starting from 4-bromo-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-62f3b4a34b2d4b879b0bca427d828b9a
来源数据集: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08642585B2
来源说明: uspto-grants-2014_02

反应 SMILES

Br[C:2]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]2[C:3]=1[CH2:4][CH2:5][C@H:6]2[O:12][C:13]1[CH:26]=[CH:25][C:16]2[C@H:17]([CH2:20][C:21]([O:23][CH3:24])=[O:22])[CH2:18][O:19][C:15]=2[CH:14]=1.Br[C:28]1[C:41]([CH3:42])=[CH:40][C:31]([C:32]([NH:34][CH2:35][C:36]([OH:39])([CH3:38])[CH3:37])=[O:33])=[CH:30][C:29]=1[CH3:43]>>[CH3:24][O:23][C:21](=[O:22])[CH2:20][C@H:17]1[C:16]2[CH:25]=[CH:26][C:13]([O:12][C@H:6]3[C:7]4[C:3](=[C:2]([C:28]5[C:41]([CH3:42])=[CH:40][C:31]([C:32](=[O:33])[NH:34][CH2:35][C:36]([OH:39])([CH3:38])[CH3:37])=[CH:30][C:29]=5[CH3:43])[CH:10]=[CH:9][C:8]=4[F:11])[CH2:4][CH2:5]3)=[CH:14][C:15]=2[O:19][CH2:18]1