Potassium Cyanide → HCID 59833602, compound

HRID 2375247Notes

Reaction equation

HRID 2375247 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](S(C)(=O)=O)[N:5]=[C:4]([NH:12][CH:13]([CH3:15])[CH3:14])[C:3]=1[C:16]1[C:21]([F:22])=[CH:20][CH:19]=[CH:18][C:17]=1[Cl:23].[C-:24]#[N:25].[K+]>C(#N)C>[Cl:1][C:2]1[C:3]([C:16]2[C:21]([F:22])=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:23])=[C:4]([NH:12][CH:13]([CH3:15])[CH3:14])[N:5]=[C:6]([C:24]#[N:25])[N:7]=1

Participants

4

Reactant 2

HCID 9032Potassium CyanideHCID 86606165HCID 86606165, compound

Product 1

HCID 59833602HCID 59833602, compoundYield 71.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 1.0 g (2.63 mmol) of sulfone 3 and 0.21 g (3.16 mmol) of potassium cyanide in acetonitrile was stirred at 20-25° C. for 5 days. The solvent was distilled off and the residue was digested with MTBE:ethyl acetate [EA] 9:1. Filtration and concentration of the filtrate gave 0.61 g of the title compound of m.p 186-188° C.

Workup

  1. distillationThe solvent was distilled off
  2. filtrationFiltration and concentration of the filtrate

Sources & evidence

ORD record
ord-9ae65ad05587474b9e2ec672e7ee74c5
Source dataset
uspto-grants-2008_12
Patent number
US07465735B2

Reaction notes

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